Whole genome sequencing
While we will not go into technical details or pros and cons here, be aware of the two main approaches to sequencing a whole genome.
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1) “Top-down” or “contig” strategy:
A physical map is needed, and the overlapping clones (a “minimal tiling path”) are sequenced in order. Since the positions of the clones (and therefore the sequences) are already known, little post-sequencing work is needed.
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