Population types for QTL mapping (4)
Near Isogenic Lines (NILs):
Advantage: Very precise and statistically strong, as background is constant; especially useful for validation experiments
Disadvantage: Can take time to construct; only useful for specific target QTL
Example: Szalma SJ, Hostert BM, LeDeaux JR, Stuber CW, Holland JB (2007) QTL mapping with near-isogenic lines in maize. Theoretical and Applied Genetics 114: 1211-1228.
See also later slide on using NILs for validation.
These are just a few of the most used types – there are many other possible populations types. Also note that outcrossing species require special considerations. See the references in the Resources at the end of this section for more details.