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Population types for QTL mapping (4)

Near Isogenic Lines (NILs):

Advantage: Very precise and statistically strong, as background is constant; especially useful for validation experiments

Disadvantage: Can take time to construct; only useful for specific target QTL

Example: Szalma SJ, Hostert BM, LeDeaux JR, Stuber CW, Holland JB (2007) QTL mapping with near-isogenic lines in maize. Theoretical and Applied Genetics 114: 1211-1228.

See also later slide on using NILs for validation.

These are just a few of the most used types – there are many other possible populations types.  Also note that outcrossing species require special considerations. See the references in the Resources at the end of this section for more details.