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“Wobble” in the code

Most amino acids are encoded by more than one codon. For example, both UUU and UUC encode phenylalanine.

Therefore, some changes in the DNA sequence, for example a point mutation (see below), do not produce a change in the amino acid sequence of the protein.

In the example below, a change in the third nucleotide from a U to a C would not result in an amino acid change as both GCU and GCC encode alanine.

 

Slide 8

Changes like this are called neutral, or synonymous mutations