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Sometimes, particularly when wild relatives are to be used for the source of introgressing new genes on a large scale or for increasing general genetic diversity (also called broadening the genetic base), the unadapted material may be put through preliminary breeding steps to create intermediate lines that are better suited for direct cultivar development.  This is called pre-breeding, or germplasm enhancement, the connecting step between genebanks and breeding programs. Molecular markers may or may not be used in the pre-breeding program.

A good example can be found in:

Acosta-Gallegos JA, Kelly JD, Gepts P (2007) Prebreeding in common bean and use of genetic diversity from wild germplasm. Crop Science 47(S3): S44-S59.